20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3971 | CASIN | Pirl1-related Compound 2 | CDK , STAT , Ras |
CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM). | |||
T27617 | Inz-1 | P450 | |
Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the path... | |||
T2620 | G-749 | G749 | Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase |
G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants. | |||
T16339 | Norverapamil hydrochloride | (±)-Norverapamil hydrochloride,D591 hydrochloride | Calcium Channel , P-gp , Drug Metabolite |
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. | |||
T15168 | DRF-1042 | Others | |
DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. | |||
T6018 | Zosuquidar trihydrochloride | Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride | P-gp |
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. | |||
T6287 | Tariquidar | XR9576 | P-gp |
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. | |||
T3S2381 | Perillene | 3-Isohexenylfuran,Perillen | Others , Antibacterial |
Perillene (3-Isohexenylfuran) is an actiive constituent in the drug which promotes enterocinesia. Perillen demonstrates strong resistance activity against staphylococcus aureus and E.coli. | |||
T7861 | Flumatinib mesylate | HHGV678 mesylate | Bcr-Abl , PDGFR , c-Kit |
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants. | |||
T0002 | Ethamsylate | Cyclonamine,Etamsylate,Dicynene,Aglumin | Prostaglandin Receptor |
Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins. | |||
T25770 | 116-9e | MAL-2-11B,MAL2-11B,MAL211B,MAL 2 11B,MAL2 11B | Virus Protease |
116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediat... | |||
T3335 | Darunavir Ethanolate | UIC 94017,Darunavir Ethanolate,TMC114 | HIV Protease |
Darunavir Ethanolate (UIC 94017) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination... | |||
T1649 | Tenofovir | PMPA,TDF,GS 1278 | HBV , HIV Protease , Reverse Transcriptase |
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIV... | |||
T36375 | Ralaniten triacetate | ||
Ralaniten triacetate (EPI-506) is a novel pro-drug of Ralaniten, functioning as an orally active inhibitor of the androgen receptor (AR) N-terminal domain (NTD). Its remarkable first-in-class status signifies its unique ... | |||
T8488 | GMB-475 | Bcr-Abl | |
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati... | |||
T2324 | Darunavir | TMC114 | HIV Protease |
Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other AN... | |||
T2328 | Radotinib | IY-5511,Supect | Bcr-Abl |
Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) w... | |||
T1496 | Amiodarone hydrochloride | Amiodar,Amiodarone HCl,Nexterone | Potassium Channel , Adrenergic Receptor , Autophagy |
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T4S1419 | (±)-Praeruptorin A | Praeruptorin A,(-)-Praeruptorin A | p38 MAPK , Calcium Channel , Akt |
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... |